Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The Michael Caligiuri Laboratory is seeking a talented and motivated Research Associate II (RA II) to join our team.

The Caligiuri lab focuses on NK cell biology, cancer immunotherapy through engineered CAR T and/or CAR NK cells, oncolytic virotherapy, antibody development, stem cell (including iPSCs) research, depending on the individual’s interests and strengths.

Under general supervision of the Principal Investigator, or designee, the RA II directs the animal work of a laboratory and/or undertakes animal (mouse) research projects in collaboration with academic supervisor, making innovative contributions pertaining to laboratory procedures which may not change the course of an investigation but, if qualified, do indicate significant independent contribution beyond the RA I level. RA II typically consults with the academic supervisor on the scope and plan of approach to a research project; reads abstracts and articles; organize and plan techniques; plan and assign the work of at least one lab staff advising on problems they are unable to solve; contribute original ideas to the laboratory research; standardize new techniques, especially with regard to mouse surgical, medical, immunologic, and radiation treatments, and train staff on these techniques as well as animal safety; once trained, perform specialized surgical procedures on laboratory animals and prepare written reports of laboratory experimental methods, especially as relates to animal work. After the academic supervisor, this RA II will be responsible for animal inventory, safety, training, and treatment oversight.

As a successful candidate, you will:

• Perform a variety of routine and non-routine laboratory animal research experiments. Record and validate results for accuracy and completeness or oversees documentation by lab members.

• Troubleshoot procedures if animal experiment results are unexpected or unsatisfactory. Recommend alternative procedures, seek and obtain IACUC approval and documents change.

• Be responsible for accurately recording IACUC protocol usage; keep protocols up to date, monitor accrual to IACUC protocols, work directly with IACUC to troubleshoot any animal issues.

• Independently evaluate research data and initiate alternative approaches to improve the quality of results by providing input to overall research design and ensure that statistical input is complete before animal experiments are launched. Train lab staff in specialized animal procedures, surgical equipment and theoretical concepts behind unique procedures.

• May contribute to the preparation of manuscripts by describing methods and specialized techniques. Keep abreast of new and improved techniques.

• Ensure that all animal laboratory activities are carried out in compliance with each procedure(s) by utilizing IACUC safety procedures and guidelines in animal handling, and in handling, storage and disposal of bio-hazardous, infectious and toxic material. Perform all animal regulatory work.

• At times when animal experiments are at a minimum, the applicant would be expected to participate in other laboratory processes and procedures, such as flow cytometry, tissue preparation, cell culture, etc.