Postdoctoral Researcher – Molecular Biology of Thyroid–Cardiovascular Signaling in Sepsis
- University of California, Davis, Medical Center
- Location: Davis, CA
- Job Number: 7322650
- Posting Date: Newly posted
- Salary / Pay Rate: 69,073.00
- Application Deadline: Jun 30, 2026
Job Description
Reports to: Dr. Jose Joaquin Lado Abeal, Professor of Medicine and Chief, IM: Endocrinology
Department Summary: The Lado Lab at UC Davis seeks a highly motivated Postdoctoral Scholar with strong molecular biology training to investigate how thyroid hormone signaling modulates cardiovascular function during septic shock.
Position Summary: Our group studies both genomic and non-genomic actions of thyroid hormones. Current projects map membrane-initiated receptor/signaling networks—spanning cytokines, growth factors, and GPCR pathways—that drive genomic, structural, and functional adaptations in the heart and vasculature. We place special emphasis on β-adrenergic desensitization, septic cardiomyopathy, and vasoplegia, with the long-term goal of informing the development of new therapeutics to improve survival in sepsis.
Approaches & Resources
You will join a collaborative team leveraging:
- Molecular biology: cloning, vector design, EMSA, protein–protein/DNA–protein interaction assays.
- Cell & tissue platforms: primary cells, iPSC-derived cardiomyocytes, tissue models.
- Imaging & physiology: live-cell biosensors, super-resolution microscopy, patch-clamp electrophysiology.
- Omics: targeted proteomics and transcriptomics.
- In vivo models: small and large-animal models of septic shock and myocardial dysfunction.
Key Responsibilities:
- Design and execute experiments; analyze and interpret data with rigor and reproducibility.
- Drive manuscripts, figures, and conference abstracts/presentations.
- Collaborate across cardiology, critical care, and biostatistics teams; mentor junior trainees as appropriate.
- Contribute to protocol/IRB/IACUC documents and lab SOPs.
Minimum Qualifications
- PhD (or equivalent) in Molecular & Cell Biology, Biochemistry, Biomedical Sciences, or a related field.
-Hands-on expertise in core molecular and cell biology( e.g., cloning/construct design, PCR/qPCR, EMSA or related DNA-binding assays, immunoblot/Co-IP, primary cell culture).
- Strong quantitative skills, clear scientific writing, and a record of productivity (publications or preprints).
Preferred Qualifications
- Experience with GPCR/β-adrenergic or thyroid hormone signaling.
- Proficiency in protein–protein interaction assays, reporter systems, or chromatin methods.
- Advanced live-cell imaging.
- Familiarity with animal models of cardiovascular disease or sepsis; AALAS/IACUC training.
Training Environment & Support
UC Davis offers an outstanding, interdisciplinary environment with access to state-of-the-art cores (genomics, imaging, proteomics) and close ties to critical care and cardiology programs. The position provides strong mentorship toward career independence and grant writing.
Appointment Details
- Start date: Flexible (review of applications begins immediately and continues until filled).
- Term: 1-year initial appointment, renewable based on performance and funding.
- Compensation: Commensurate with experience and aligned with UC/NIH guidelines; full UC benefits.
How to Apply
Email a single PDF to Joaquin Lado, MD, PhD at [email protected] with:
1) Cover letter describing your research interests and fit,
2) CV, and
3) Names/contact information for three references.
Department Summary: The Lado Lab at UC Davis seeks a highly motivated Postdoctoral Scholar with strong molecular biology training to investigate how thyroid hormone signaling modulates cardiovascular function during septic shock.
Position Summary: Our group studies both genomic and non-genomic actions of thyroid hormones. Current projects map membrane-initiated receptor/signaling networks—spanning cytokines, growth factors, and GPCR pathways—that drive genomic, structural, and functional adaptations in the heart and vasculature. We place special emphasis on β-adrenergic desensitization, septic cardiomyopathy, and vasoplegia, with the long-term goal of informing the development of new therapeutics to improve survival in sepsis.
Approaches & Resources
You will join a collaborative team leveraging:
- Molecular biology: cloning, vector design, EMSA, protein–protein/DNA–protein interaction assays.
- Cell & tissue platforms: primary cells, iPSC-derived cardiomyocytes, tissue models.
- Imaging & physiology: live-cell biosensors, super-resolution microscopy, patch-clamp electrophysiology.
- Omics: targeted proteomics and transcriptomics.
- In vivo models: small and large-animal models of septic shock and myocardial dysfunction.
Key Responsibilities:
- Design and execute experiments; analyze and interpret data with rigor and reproducibility.
- Drive manuscripts, figures, and conference abstracts/presentations.
- Collaborate across cardiology, critical care, and biostatistics teams; mentor junior trainees as appropriate.
- Contribute to protocol/IRB/IACUC documents and lab SOPs.
Minimum Qualifications
- PhD (or equivalent) in Molecular & Cell Biology, Biochemistry, Biomedical Sciences, or a related field.
-Hands-on expertise in core molecular and cell biology( e.g., cloning/construct design, PCR/qPCR, EMSA or related DNA-binding assays, immunoblot/Co-IP, primary cell culture).
- Strong quantitative skills, clear scientific writing, and a record of productivity (publications or preprints).
Preferred Qualifications
- Experience with GPCR/β-adrenergic or thyroid hormone signaling.
- Proficiency in protein–protein interaction assays, reporter systems, or chromatin methods.
- Advanced live-cell imaging.
- Familiarity with animal models of cardiovascular disease or sepsis; AALAS/IACUC training.
Training Environment & Support
UC Davis offers an outstanding, interdisciplinary environment with access to state-of-the-art cores (genomics, imaging, proteomics) and close ties to critical care and cardiology programs. The position provides strong mentorship toward career independence and grant writing.
Appointment Details
- Start date: Flexible (review of applications begins immediately and continues until filled).
- Term: 1-year initial appointment, renewable based on performance and funding.
- Compensation: Commensurate with experience and aligned with UC/NIH guidelines; full UC benefits.
How to Apply
Email a single PDF to Joaquin Lado, MD, PhD at [email protected] with:
1) Cover letter describing your research interests and fit,
2) CV, and
3) Names/contact information for three references.
