Postdoc Fellow/Research Scientist Studying Epigenetic/Transcriptional Gene Regulation in Breast Cancer
- UC College of Medicine
- Location: Cincinnati, OH
- Job Number: 7195633
- Posting Date: Nov 22, 2023
- Application Deadline: Open Until Filled
Job Description
Supported by our NCI R01 grants, Zhang Lab at the Department of Cancer Biology at the University of Cincinnati (https://med.uc.edu/zhanglab) has openings for Research Scientist and Postdoctoral Fellow to study transcriptional and epigenetic gene regulation in breast cancer metastasis and therapeutic resistance. The Zhang laboratory currently focuses on elucidating the role and molecular mechanisms of gene- and tissue-specific transcriptional cofactors, small RNAs (e.g. miRNA, enhancer RNA), and Liquid-Liquid Phase Separation (LLPS) in these processes in breast cancer cells and tumor immune microenvironment [Estrogen Receptor and Breast Cancer – Celebrating the 60th Anniversary of the Discovery of ER (1st ed, 2019, Springer Nature), Dev Cell (2021)56(3):341, Cell Reports (2021) 34(10):108822, Cancer Drug Resist 2022; 5(2): 498, Autophagy (2023) 19(6):1662]. We are using a combination of biochemical, molecular, multi-omics, and mouse genetic (conditional knockout, mutant knockin, and overexpression) approaches. We are also currently developing our patented RNA nanotherapeutics (https://rnanano.com) to target these cofactors and small RNAs to overcome the therapeutic resistance of human breast cancer.
Interested candidates must have a Ph.D. and/or M.D. degree with research experience in biochemistry, molecular or cellular biology. Prior experience with small RNAs, genomics, LLPS, or animal studies is a plus. Salary is competitive with an attractive benefits package that includes family health insurance, retirement contributions, etc. Please submit a CV and list of contact information for three references to:
Xiaoting Zhang, Ph.D.
Professor and John and Glydas Strauss Endowed Chair
Director, Breast Cancer Research Program
Department of Cancer Biology
University of Cincinnati College of Medicine
3125 Eden Avenue
Cincinnati, OH 45267
Email: zhangxt@ucmail.uc.edu
Web: https://med.uc.edu/zhanglab
Web: https://med.uc.edu/BCRP
Founded in 1819, the University of Cincinnati embarks upon its third century – building on the past and defining the future by leading urban, public universities into a new era of innovation and impact through its strategic direction, Next Lives Here. The University of Cincinnati is ranked as one of America’s top 26 public research universities by the National Science Foundation. The university boasts a diverse student body of over 47,000 enrolled in over 370 programs of study and is the region’s largest employer with over 15,000 faculty, staff and student workers. The university combines its Research 1 (Very High Research Activity) Carnegie Classification with a physical setting that The New York Times recently acclaimed as “the most ambitious campus design program in the country. Cincinnati has been identified as one of the most livable cities in the US with an affordable and big city lifestyle of sports, art, entertainment, and more.
Interested candidates must have a Ph.D. and/or M.D. degree with research experience in biochemistry, molecular or cellular biology. Prior experience with small RNAs, genomics, LLPS, or animal studies is a plus. Salary is competitive with an attractive benefits package that includes family health insurance, retirement contributions, etc. Please submit a CV and list of contact information for three references to:
Xiaoting Zhang, Ph.D.
Professor and John and Glydas Strauss Endowed Chair
Director, Breast Cancer Research Program
Department of Cancer Biology
University of Cincinnati College of Medicine
3125 Eden Avenue
Cincinnati, OH 45267
Email: zhangxt@ucmail.uc.edu
Web: https://med.uc.edu/zhanglab
Web: https://med.uc.edu/BCRP
Founded in 1819, the University of Cincinnati embarks upon its third century – building on the past and defining the future by leading urban, public universities into a new era of innovation and impact through its strategic direction, Next Lives Here. The University of Cincinnati is ranked as one of America’s top 26 public research universities by the National Science Foundation. The university boasts a diverse student body of over 47,000 enrolled in over 370 programs of study and is the region’s largest employer with over 15,000 faculty, staff and student workers. The university combines its Research 1 (Very High Research Activity) Carnegie Classification with a physical setting that The New York Times recently acclaimed as “the most ambitious campus design program in the country. Cincinnati has been identified as one of the most livable cities in the US with an affordable and big city lifestyle of sports, art, entertainment, and more.
