Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

Position Summary

The Brenner laboratory is broadly interested in nicotinamide adenine dinucleotide (NAD) metabolism in health and disease. Active research projects include dysregulation of NAD in cancer, perturbations by nicotine, alterations of the NAD system in rare diseases, and alterations of the NAD system in diabesity, infection and neuropathy. The laboratory uses tools of molecular biology, biochemistry, cell biology, metabolomics and mouse modeling to uncover regulatory systems. Our work has led to dozens of clinical trials in diverse areas including blood pressure regulation, preservation of neurocognitive functions, fatty liver, lactation and recovery from SARS-CoV2.

There are current laboratory openings for Postdoctoral Fellows and Research Associate I.

We have placed dozens of former trainees in MD, DVM and PhD programs. Our former graduate students and post-docs have excellent positions in academia and industry. We are a hard working but supportive group and live in a beautiful area 10 minutes from San Gabriel Mountain hiking, 60 minutes from beaches and 90 minutes from skiing.

About City of Hope

City of Hope is an independent research and treatment center for diabetes, cancer and other life-threatening diseases. Bringing together the best in bench-to bedside research, City of Hope’s Arthur Riggs Diabetes & Metabolism Research Institute (AR-DMRI) is one of the world’s most comprehensive diabetes research programs.

City of Hope has a long and impressive history of groundbreaking discoveries in the field of diabetes spanning more than five decades since Rachmiel Levine, M.D., who discovered the role of insulin in glucose transport, launched diabetes research at City of Hope in the 1970s. The Institute is named for Arthur D. Riggs, Ph.D., another pioneer in the field famous for his work on synthesizing the first man-made gene and using synthetic genes to produce human insulin, now the standard of care for people with diabetes worldwide. The AR-DMRI is headed by Debbie Thurmond, Ph.D., a renowned research scientist, professor and founding chair of the Department of Molecular & Cellular Endocrinology.

City of Hope is also home to seminal National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) programs, such as the Human Islet Research Network (HIRN) and the Integrated Islet Distribution Program (IIDP), that lead the field of diabetes in diabetes research and translational potential.

City of Hope is located in Los Angeles, California, with community clinics throughout Southern California. It recently acquired Cancer Treatment Centers of America, extending its national reach. One of only 53 NCI-designated comprehensive cancer centers in the nation, it has been ranked as one of "America's Best Hospitals" in cancer by U.S. News & World Report for over 15 years. Founded in 1913, City of Hope is a pioneer in the fields of immunotherapy and clinical islet cell transplantation for diabetes, bone marrow transplantation and numerous breakthrough cancer drugs, many based on technology developed at the institution.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Basic education, experience and skills required for consideration:

· For Postdoctoral Fellows, must have a PhD with publications and experience in techniques and/or research of relevance to the Brenner research group.

· For Research Associate I, must have a BA/BS degree with some research experience and be on a sound quantitative footing.

Additional Information:

To apply, please read some papers at https://www.brennerlab.net/curriculumvitae/ (Particularly good papers to read are 122, 129, 135 and 144) and send a letter of interest describing your graduate work and demonstrating your thoughts on how the laboratory might proceed to dissect metabolic processes of interest to Dr. Charles Brenner at [email protected]

Postdoctoral Fellow

Pay Rate: $31.00 – 34.23

Research Associate I

Pay Rate: $24.51 – 28.43

The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

The Postdoctoral Fellowship and Research Associate I positions do qualify for City of Hope's full-time comprehensive benefits package. This is includes healthcare options, paid time off, retirement plan, tuition reimbursement, life insurance and wellness programs.

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.