Postdoctoral Fellow
- The National Institutes of Health
- Location: Bethesda, MD
- Job Number: 7140650
- Posting Date: Apr 18, 2023
- Application Deadline: Open Until Filled
Job Description
Department of Health and Human Services
National Institutes of Health
National Heart, Lung, and Blood Institute
Postdoctoral Fellow
A postdoctoral fellow position is available in Haiming Cao’s laboratory in the Cardiovascular Branch of NIH, National Heart, Lung, and Blood Institute. The Cao group studies the molecular and pathological mechanisms of human diseases particularly diabetes, cardiovascular disorders and non-alcoholic steatohepatitis (NASH) with the goal of finding effective therapies. In recent years, the lab has developed wet-lab and computational approaches to identify and functionally characterize disease-associated long noncoding RNAs (lncRNAs). The lab is among the first to demonstrate the importance of lncRNAs in glucose and lipid metabolism in mice (Cell Metabolism, 2016, Cell Reports, 2016 and Cell Metabolism, 2015). As most human lncRNAs are non-conserved, the lab has recently developed two pipelines leveraging the information of genome-wide association studies (Nature Communications, 2020) and clinical studies of metabolic disorders (JCI, 2021) to systematically identify disease-relevant human lncRNAs, and has also defined the pathological role of selected human lncRNAs using a liver-specific humanized mouse model. In coming years, the lab will use machine learning to infer lncRNAs’ function and structure, and will define their physiological role and therapeutic potential in humanized mouse models. More information on the Cao group is available at http://www.nhlbi.nih.gov/research/intramural/researchers/pi/cao-haiming.
The Cao lab is supported by mouse transgenic, human iPS, high-throughput sequencing, proteomics, advanced microscopy, animal surgery and bioinformatics core facilities. The lab also has direct access to Biowulf, the largest high-performance computing systems for biomedical research in the world that features a 105,000+ processor cluster. With an interdisciplinary research environment and strong emphasis on novel informatics technology in life science, this position provides a unique opportunity for recent PhD awardees to deepen and broaden their research profile for advancing to an independent academic career.
QUALIFICATIONS: Interested candidates must be completing or should have obtained a Ph.D. or M.D. degree with background in Molecular Biology, Cell Biology, Biochemistry, Genetics, Physiology, Bioinformatics, Computational Biology or a related discipline and less than 5 years’ postdoctoral experience. Experience in mouse models of metabolic disorders, RNA biology, bioinformatics and computational biology are highly desirable but not required. In general, quality of past research is more important than experience in a specific field.
STIPEND/BENEFITS: These positions are fully supported by NIH intramural funds and successful candidates will be offered competitive stipend/health insurance commensurate with experience and accomplishments.
Applications from women, minorities and persons with disabilities are strongly encouraged. Applicants should send curriculum vitae and 3 letters of reference to be sent (via email only) to: [email protected]. Applications will be continuously reviewed until the position is filled.
The NIH is dedicated to building a diverse community in its training and employment programs.
HHS and NIH are Equal Opportunity Employers
National Institutes of Health
National Heart, Lung, and Blood Institute
Postdoctoral Fellow
A postdoctoral fellow position is available in Haiming Cao’s laboratory in the Cardiovascular Branch of NIH, National Heart, Lung, and Blood Institute. The Cao group studies the molecular and pathological mechanisms of human diseases particularly diabetes, cardiovascular disorders and non-alcoholic steatohepatitis (NASH) with the goal of finding effective therapies. In recent years, the lab has developed wet-lab and computational approaches to identify and functionally characterize disease-associated long noncoding RNAs (lncRNAs). The lab is among the first to demonstrate the importance of lncRNAs in glucose and lipid metabolism in mice (Cell Metabolism, 2016, Cell Reports, 2016 and Cell Metabolism, 2015). As most human lncRNAs are non-conserved, the lab has recently developed two pipelines leveraging the information of genome-wide association studies (Nature Communications, 2020) and clinical studies of metabolic disorders (JCI, 2021) to systematically identify disease-relevant human lncRNAs, and has also defined the pathological role of selected human lncRNAs using a liver-specific humanized mouse model. In coming years, the lab will use machine learning to infer lncRNAs’ function and structure, and will define their physiological role and therapeutic potential in humanized mouse models. More information on the Cao group is available at http://www.nhlbi.nih.gov/research/intramural/researchers/pi/cao-haiming.
The Cao lab is supported by mouse transgenic, human iPS, high-throughput sequencing, proteomics, advanced microscopy, animal surgery and bioinformatics core facilities. The lab also has direct access to Biowulf, the largest high-performance computing systems for biomedical research in the world that features a 105,000+ processor cluster. With an interdisciplinary research environment and strong emphasis on novel informatics technology in life science, this position provides a unique opportunity for recent PhD awardees to deepen and broaden their research profile for advancing to an independent academic career.
QUALIFICATIONS: Interested candidates must be completing or should have obtained a Ph.D. or M.D. degree with background in Molecular Biology, Cell Biology, Biochemistry, Genetics, Physiology, Bioinformatics, Computational Biology or a related discipline and less than 5 years’ postdoctoral experience. Experience in mouse models of metabolic disorders, RNA biology, bioinformatics and computational biology are highly desirable but not required. In general, quality of past research is more important than experience in a specific field.
STIPEND/BENEFITS: These positions are fully supported by NIH intramural funds and successful candidates will be offered competitive stipend/health insurance commensurate with experience and accomplishments.
Applications from women, minorities and persons with disabilities are strongly encouraged. Applicants should send curriculum vitae and 3 letters of reference to be sent (via email only) to: [email protected]. Applications will be continuously reviewed until the position is filled.
The NIH is dedicated to building a diverse community in its training and employment programs.
HHS and NIH are Equal Opportunity Employers