About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution.  AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities.  Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding.  We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

The Bioinformatics Postdoctoral Fellow will work in a team environment in Andrea Bild’s lab studying tumor heterogeneity using whole genome sequencing and single cell sequencing approaches, among others. The project will focus on our funded NIH Cancer Systems Biology Consortium (https://csbconsortium.org/) program at City of Hope Comprehensive Cancer Center and provide exciting opportunities to engage with top scientists and cutting edge genomic research.  This translational research position works in a leading team of cancer biologists, mathematicians, clinicians, and bioinformaticians.

Key Responsibilities include:

For this position, the scientist will lead efforts to analyze high throughput sequencing data from patient tumors for detection of tumor heterogeneity and evolution of resistant traits using single cell RNA-sequencing and WGS (for reference, please read: https://pubmed.ncbi.nlm.nih.gov/34712959/; https://www.ncbi.nlm.nih.gov/pubmed/29093439). S/he will manage the analysis and interpretation of genomics data from patient cohorts in order to understand why cancer progresses and the traits of resistant tumor subclones the emerge during therapy. The successful candidate will also contribute to the development data workflow processes and pipelines. S/he will also have the opportunity to assist in training investigators and new users to use bioinformatics applications and databases.

Basic education, experience and skills required for consideration:

• PhD degree in bioinformatics or equivalent and experience with NGS sequencing data.
• Demonstrated ability to solve biologically-relevant problems requiring using genomic data analysis.
• Ability to analyze data of high complexity by applying sound statistical and commonly accepted bioinformatics methods to -omics data with a collaborative project team.
• Excellent English written and oral communication skills.
• Excellence in scripting languages (python, perl) and with R.

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer.  All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.