Postdoctoral Fellow - Animal Models for Hematological Research
- City of Hope
- Location: Monrovia, CA
- Job Number: 7091931 (Ref #: 10011397)
- Posting Date: Aug 25, 2022
- Application Deadline: Open Until Filled
Job Description
About City of Hope
City of Hope is an independent biomedical research and treatment organization for cancer, diabetes, and other life-threatening diseases.
Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.
A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.
City of Hope’s commitment to Diversity, Equity, and Inclusion
We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds, and experiences to our work -- and that our teams align with the people we serve to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds, and perspectives; this is reflected in our work and represented in our people.
Position Summary
A Postdoctoral Fellow position is open in the laboratory of Dr. Guido Marcucci in the Department of Hematological Malignancies Translational Sciences at the City of Hope Beckman Research Institute. The Marcucci laboratory studies the pathogenesis of acute myeloid leukemia (AML) and development of new treatments for AML based on these discoveries.
Work in the lab utilizes both genetically engineered mouse models, patient-derived AML xenograft models, and in vitro systems. Techniques commonly used in the lab include: molecular biology, protein characterization including western blotting, flow cytometry, immunology, tissue culture, and microscopy, including the use of fluorescent probes.
The following projects are presently being pursued:
- Antibody-based therapeutics directed against AML and related myeloid malignancies
- Chimeric antigen receptor (CAR) T cell-based therapeutics
- Discovery of neoantigens and identification of HLA-restricted epitopes derived from them
We seek an independent and highly motivated candidate interested in studying the molecular, cellular, and metabolic mechanisms leading to AML and resistance to therapy.
Basic education, experience and skills required for consideration:
- Ph.D., M.D., or D.V.M. degree or combinations thereof in life or biomedical sciences or a related discipline
- Experience in basic molecular biology
- Experience in animal models
- Experience in techniques used in immunology research
- Excellent written and verbal communication skills
- Good problem-solving skills, ability to conduct independent research, ability to work effectively in a team in a fast-paced environment
Additional Information:
As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.
- For a complete list of Publications please visit here: https://www.ncbi.nlm.nih.gov/sites/myncbi/guido.marcucci.1/bibliography/40967843/public/?sort=date&direction=descending
- To Apply, please attach a cover letter describing your past training and research interests, a detailed CV and contact information of three referees
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
#PD
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.
