Role of Cellular Factors in Viral Replication (Postdoctoral Position)
- Albert Einstein College of Medicine
- Location: New York, NY
- Job Number: 7075594
- Posting Date: Mar 2, 2021
- Application Deadline: Apr 2, 2021
Highly motivated, ambitious, driven and talented postdoctoral fellows are sought to join the Diaz-Griffero Lab in New York, a research program that studies the role of cellular factors on viral replication to understand viral-host interactions. Our program has made important contributions to the mechanisms by which HIV-1 productively infect human primary T cells and has recently developed several assays to capture cellular factors that contribute to infection using mass spectrometry and developed high-throughput assays for the discovery of antivirals. Our interdisciplinary program has a robust set of global collaborations, which strengthen our scientific capabilities. The individual is expected to join a fast pace moving environment. Career development including attendance to conferences is strongly supported. The laboratory is located in the new Price Center Building, a recently constructed state-of-the-art biomedical research facility centrally located on the campus of the Albert Einstein College of Medicine in New York. Funding is currently available for up to 3 years, with the possibility of further extensions.
This program aims to gain biochemical, cellular biological, and in vivo(mouse) understanding of the mechanism by which host proteins assist viral replication. Requirements: a) Recent Ph.D. or M.D./Ph.D. degree. b) Experience in molecular biology (cloning, shRNA, CRISPR/Cas9, real-time PCR, Western blot), cell biology (microscopy, immunofluorescence and tissue culture), and biochemistry (subcellular fractionation, immunoprecipitations,etc) is desired. c) experience working with human primary T cells and mouse models is desired.
Applicants must have at least 1 paper in a peered reviewed journal. Please send a CV, and names for up to three references by email to Felipe Diaz-Griffero (email@example.com).
Selyutina, A., Persaud, M., Lee, K., KewalRamani, V., and Diaz-Griffero, F. (2020a). Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating. Cell Rep 32, 108201.
Selyutina, A., Persaud, M., Simons, L.M., Bulnes-Ramos, A., Buffone, C., Martinez-Lopez, A., Scoca, V., Di Nunzio, F., Hiatt, J., Marson, A., et al. (2020b). Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5alpha Binding to the Viral Core. Cell Rep 30, 3766-3777 e3766.
Yu, C.H., Bhattacharya, A., Persaud, M., Taylor, A.B., Wang, Z., Bulnes-Ramos, A., Xu, J., Selyutina, A., Martinez-Lopez, A., Cano, K., et al. (2021). Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nature communications 12, 731.
The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Einstein seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence, and the communities we serve.