Job Description

Postdoctoral Associates
Dr. Jun-Lin Guan Laboratory
UNIVERSITY of CINCINNATI College of Medicine

Postdoctoral positions are available to pursue basic and translational cancer research in Dr. Jun-Lin Guan’s laboratory at University of Cincinnati College of Medicine. Research in Dr. Guan’s laboratory aims to understand the fundamental principles of cell signaling in the regulation of basic cellular functions in normal cell and developmental processes and to determine how the disruption of normal signaling pathways lead to diseases such as cancer. Current studies include the analysis of autophagy and non-canonical functions of multiple autophagy genes in breast cancer and neural stem cells, and mTORC1 signaling in vascular and other tumors and its cross-talk with autophagy. We use a variety of genetically engineered mouse models combined with molecular, cellular and functional genomic approaches as well as CRISPR-based genetic screen, single cell transcriptomics, PROTACs, organoids and optogenetics to gain mechanistic insights of complex signaling networks in vivo. Please see Dev Cell 2021 (http://doi.org/10.1016/j.devcel.2020.12.016), Cancer Res. 2020 (https://cancerres.aacrjournals.org/content/early/2020/06/24/0008-5472.CAN-20-0519), Elife 2020 (https://doi.org/10.7554/eLife.58810), Nature Metabolism 2019 (https://www.nature.com/articles/s42255-019-0137-5), JCB 2017 (https://rupress.org/jcb/article/216/8/2581/39169/Autophagy-gene-FIP200-in-neural-progenitors-non), Genes Dev. 2016 (http://genesdev.cshlp.org/content/30/7/856.full), Cancer Res. 2016 (https://cancerres.aacrjournals.org/content/76/11/3397), and Cancer Cell 2015 (http://dx.doi.org/10.1016/j.ccell.2015.10.004) for a selection of recent studies from our laboratory.

The Department of Cancer Biology in the University of Cincinnati College of Medicine provides a dynamic, interactive and supportive environment. We are a well-established laboratory with extensive experiences and contributions in cancer research as well as strong training record for postdocs over 3 decades at Cornell University, University of Michigan, and University of Cincinnati. Please see https://med.uc.edu/depart/cancer-biology/about/chair about Dr. Guan and visit https://med.uc.edu/depart/cancer-biology/labs/guan-laboratory for more information on our laboratory. We are interested in recruiting self-motivated, recent Ph.D. or M.D./Ph.D. graduates with the drive to succeed and the desire to be competitive at the highest level. Candidates with a strong background in cell and molecular biology, cancer research, neuroscience, vascular biology and/or immunology are encouraged to apply. Experience in autophagy, cell signaling, vesicle trafficking, single-cell transcriptional and genomic analysis, stem cells, and mouse models of cancer, neurodegenerative or other diseases are preferred.

The University of Cincinnati is a premier, public, urban research university, ranked as one of America’s top 26 public research universities by the National Science Foundation. U.S. News & World Report has ranked UC in the Top Tier of America’s Best Colleges. The College of Medicine is the No. 44 Medical School for Research. The 2018 Nature index of Life Science for the University of Cincinnati is ranked as 85 out of ~3000 Institutes worldwide. In the Web of Sciences ESI ranking, all research catalogs related biology and medicine for University of Cincinnati fall into top 1% globally.

MINIMUM QUALIFICATIONS: PhD. or M.D./PhD.

Application Process: Create an 'Applicant Profile' at https://jobs.uc.edu/ and upload your CV/Resume and contact information of three (3) references. Officially apply to https://bit.ly/2MYBiCL and under the 'Additional Documents' section of the application upload a short statement of research interest.

For additional information concerning this position you may contact Jun-Lin Guan, Ph.D. Professor and Chair, Department of Cancer Biology, University of Cincinnati College of Medicine, Vontz Center for Molecular Studies Rm 3324, 3125 Eden Avenue Cincinnati, OH 45267-0521. E-mail: guanjl@uc.edu. Tel/Fax: (513) 558-0114/(513) 558-1190.

The University of Cincinnati, as a multi-national and culturally diverse university, is committed to providing an inclusive, equitable and diverse place of learning and employment. As part of a complete job application you will be asked to include a Contribution to Diversity and Inclusion statement.

As a UC employee, and an employee of an Ohio public institution, if hired you will not contribute to the federal Social Security system, other than contributions to Medicare. Instead, UC employees have the option to contribute to a state retirement plan (OPERS, STRS) or an alternative retirement plan (ARP).

The University of Cincinnati is an Affirmative Action / Equal Opportunity Employer / Minority / Female / Disability / Veteran.