Postdoctoral Fellow - Lymphoma Research
- City of Hope
- Location: Duarte, CA
- Job Number: 7073386 (Ref #: 10007774rxv_113_1)
- Posting Date: Dec 21, 2020
- Application Deadline: Open Until Filled
Job DescriptionAbout City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
We are seeking goal-oriented, highly motivated Postdoctoral Fellow with a passion for science to lead translational immuno-oncology projects.
The main goal of our laboratory is the translational development of immunotherapies for lymphoma. We have a keen interest in understanding how tumor-cell intrinsic mechanisms regulate the endogenous immune response against lymphoma, and how this informs pathways driving response and resistance to immune-based treatments in this disease. We aim to leverage this information to 1) develop novel biomarkers that promote precision-based medicine and 2) discover strategies to further enhance the efficacy of existing immunotherapies.
The lab employs syngeneic and genetically engineered pre-clinical mouse models, as well as patient specimens, in both basic and translational studies of lymphoma. We also use an array of cellular, molecular, and genomic analyses to interrogate questions in several in vitro, in vivo, and bioinformatic studies.
The ideal candidate will have relevant laboratory experience in one more of the following areas of molecular biology and cellular immunology including:
- Molecular biology techniques:
- qPCR and Western blots
- Gene editing via CRISPR/Cas9
- Experience with -omics platforms (genomics, epigenomics)
- Cellular immunology techniques including
- Multi-parameter flow cytometry of mouse and human samples
- Cell culture of mouse and human cells, including cell lines and primary cells
- Experience working with lab animals and animal husbandry
- Syngeneic, transplantable tumor models
- Familiarity with developing and utilizing genetically engineered mouse models
Basic education, experience and skills required for consideration:
- Doctorate degree (Ph.D. or M.D.) required
- A background within molecular biology, cellular immunology and working with lab animals and husbandry is preferred.
- Basic computational biology skills will also be very valuable but are not mandatory for the position.
- For more information on Dr. Godfrey and the Toni Stephenson Lymphoma Center please visit, here
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.