Postdoctoral Associate - Molecular & Cellular Biology - Xi Chen (90007701)
- Baylor College of Medicine
- Location: Houston, TX
- Job Number: 7073352 (Ref #: 5608-en_US)
- Posting Date: Dec 18, 2020
- Application Deadline: Open Until Filled
Job Description
Job Purpose
Postdoctoral Associate who will be performing scientific research in the area of breast cancer: Dr. Chen's laboratory studies the function and mechanism of Endoplasmic Reticulum (ER) protein quality control machinery in tumor microenvironment, therapy resistance and stem cell niche. This specifics of this research target is to study the function and mechanism of Endoplasmic Reticulum (ER) protein quality control machinery in cancer progression, metastasis and therapy resistance, with special focus on cancer immunotherapy. Our long-term goals is to elucidate the significance and mechanisms of ER proteostasis in cancer progression, metastasis and therapy resistance, and developing mechanism-based novel therapies to overcome therapy resistance and transform cancer to a manageable chronic disease. Our recent study revealed an unprecedented role of the IRE1a/XBP1 branch of the UPR in mediating tumor homeostasis and therapy resistance. We have developed a mechanism-based combination therapy with the IRE1a RNase inhibitor and docetaxel that completely eradicated the primary patient-derived breast tumors, prevented recurrence and triggered robust immune response.
Job Duties
- Plans, directs and conducts specialized and advanced research experiments.
- Evaluates and analyzes data.
- May establish new research protocols and procedures.
- Summarizes research findings and publish results in research journals.
- May be responsible for laboratory operations.
Minimum Qualifications
- MD or Ph.D in Basic Science, Health Science, or a related field. Strong background and working knowledge in immunology and cancer biology.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
5608
Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.
