Job Description

Project Overview

Immunogenicity is a significant challenge in the development of safe and effective AAV-based gene therapies. We are developing a high-throughput computational and experimental platform for assessing immunogenicity and designing and testing deimmunized protein variants. Our goal is to create AAV gene therapy vectors with reduced immunogenicity profiles.

Responsibilities

Molecular immunology techniques and high throughput screening technologies will be used to assay immunogenicity and function of designed AAVs. The candidate will work primarily on
• AAV production, functional profiling, and immunogenicity assays
• MHC peptide display & stability
• T cell activation in vitro
• Rodent-based T cell and antibody response

Desired knowledge and experience
• Experience with molecular immunology assays (esp. MHC and T cell) is highly desired
• Experience with AAV is highly desired
• Strong knowledge in immunology
• Ability to work independently to design and troubleshoot experiments
• Ability to work effectively within a broader team with complementary expertise
• Ability to supervise a technician on the project

Requirements

• Ph.D in Immunology, Bioengineering, Biochemistry, Biology, or related fields
• Experience with molecular immunology assays
• Strong knowledge of molecular biology and immunology
• Experience with AAV is a plus
• Experience with high throughput assay development is a plus
• Good communication skills and ability to oversee a lab technologist


To apply, please visit our website at: http://smart.mit.edu/careers/career-opportunities. Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.