Postdoctoral Fellow - DNA Repair and Damage
- City of Hope
- Location: Duarte, CA
- Job Number: 7072309 (Ref #: 10008338)
- Posting Date: Nov 19, 2020
- Application Deadline: Open Until Filled
Job DescriptionAbout City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
Postdoctoral positions are now available in the laboratory of Dr. Terence Williams, MD, PhD in the Department of Radiation Oncology, Cancer Genetics and Epigenetics within the Beckman Research Institute of City of Hope. Applicants should be highly motivated, creative, independent fast learner, with strong work ethic and critical-thinking abilities, seeking to perform high-impact research and publish in high-impact journals. Dr. Williams’ laboratory focuses on DNA repair, DNA damage response signaling, tumor metabolism, nutrient scavenging, and autophagy in multiple cancer types, including lung cancer, pancreatic cancer, thyroid cancer, colorectal cancer, brain tumors, etc. As examples of his work, Dr. Williams’ lab was the first to identify a role for caveolae/Cav-1 in albumin uptake and nutrient scavenging, as well as important roles for BRAF and KRAS mutations in DNA repair and response to genotoxic therapies, including radiation. His lab actively studies caveolae-mediated endocytosis as a target for cancer therapy, how oncogenes (e.g. KRAS, BRAF) mediate resistance to therapy, how to harness cell cycle and cell cycle checkpoint repair pathways for therapeutic intent (e.g. Wee1, ATR, Chk1), developing novel RNA-based nanotherapeutics and protein-drug conjugates, and novel RNA-based signatures to predict outcomes and therapeutic response. Dr. Williams’ lab research studies span across cell line modeling, animal modeling (e.g. including transgenic mouse and patient-derived models), to research with human tissues from patients with cancer.
The long-term goals of the research are to better understand the underlying molecular mechanisms of how cancer cells perform nutrient scavenging as well as how oncogenes regulate DNA repair and DNA damage response signaling after therapy, which will hopefully lead to the identification of key molecular targets that engender improvements of therapy in solid tumors. His lab is dedicated to translational research, assessing molecular alterations in cancer models and patient tissues, and obtaining novel insights from the bedside.
Basic education, experience and skills required for consideration:
- A Ph.D. degree in life or biomedical sciences, or a related discipline is required.
- Proficiency in molecular and cellular biology, biochemistry, cancer biology and/or animal (mouse) studies is required.
- Dr. Williams research is currently supported by multiple NIH R01s, American Cancer Society, Radiation Oncology Institute, Florida Biomedical Research Program, NCCN, and internal funds.
- Research findings from Dr. Williams’ research group have been published in Clinical Cancer Research, Cancer Research, Molec Cancer Therapeutics, Oncotarget, J Clin Invest, J Clin Oncology, J Thoracic Oncol, PNAS, Cancer, JAMA Surgery, IJROBP, R&O, J Biol Chem, Molec Biol Cell, Cell Cycle, and numerous other journals.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.