Postdoctoral Fellow - Development of Quantitative Super-Resolution Approaches for Assessing Alcohol Use Disorders
- City of Hope
- Location: Duarte, CA
- Job Number: 7071382 (Ref #: 10008117)
- Posting Date: Oct 24, 2020
- Application Deadline: Open Until Filled
Job DescriptionAbout City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
A Postdoctoral Fellow Position is available for an industrious individual to work on a project focused on advancing quantitative single molecule localization microscopy (qSMLM) to study alcohol use disorders. The Position will use advanced microscopy methods to assess how alcohol perturbs the dynamic organization of signaling domains that harbor opioid receptors: Ethanol and Naltrexone Have Distinct Effects on the Lateral Nano- organization of Mu and Kappa Opioid Receptors in the Plasma Membrane (ACS Chemical Neuroscience, 2019, Tobin et al.). Acute exposure to ethanol affects both the clustering and nano-organization of opioid receptors; such effects may be impeded by the drug naltrexone. This National Institutes of Health (NIH) funded Position will probe the nano-organization of kappa and mu opioid receptors in cultured cells and rat brains.
Key Responsibilities include:
- The Position involves (but is not limited to) designing and executing studies that comprise the following activities: cell culture, plasmid transfection, antibody labeling and validation; immunostaining of cells and rat brain slices; qSMLM imaging (PALM and dSTORM); analysis of qSMLM data using established algorithms; development of new codes (MATLAB) to process qSMLM data.
- The Position is expected to work independently, work collaboratively with other lab-members, and work productively with the Principle Investigator (Dr. Jovanovic-Talisman). A successful candidate will deftly balance these activities and meet NIH milestones.
Basic education, experience and skills required for consideration:
- A Ph.D. degree in biomedical sciences, biophysics, chemical engineering or a related discipline is required with no more than 3 years of postdoctoral training; experience in quantitative microscopy, cell biology, and MATLAB programing; ability to carry out independent research and prepare manuscripts for publication.
- Super-resolution microscopy experience is highly preferred.
- For more information on Dr. Talisman’s research, please click here .
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.