Postdoc scholars who love science and dare to invent
- University of California San Diego
- Location: San Diego, CA
- Job Number: 7066908
- Posting Date: Jun 14, 2020
- Application Deadline: Open Until Filled
Job DescriptionWe welcome bold minds who will innovate in the areas of RNA biology, spatial transcriptomics, single-cell technologies, the human protein interactome, extracellular RNA, blood vessels and endothelial cells, Diabetes, and Alzheimer’s disease.
About the PI
Sheng Zhong is a Professor of Bioengineering at UC San Diego. His received an NIH Director's Pioneer Award, an NIH Director’s New Innovator Award, an NSF CAREER Award, and an Alfred Sloan Fellowship. He is a fellow of American Institute for Medical and Biological Engineering (AIMBE) and the director for NIH Common Fund 4D Nucleome Consortium Organizational Hub. He leads a Human Cell Atlas (HCA) seed network on single cell analysis of human blood vessels. Eight of his previous trainees are contributing to science on tenure-track faculty positions.
About the lab
Our lab invented the MARIO (Mapping RNA interactome in vivo) technology to massively reveal RNA-RNA interactions from human tissue (Nat Comm, 2016). We also invented the MARGI (Mapping RNA-Genome Interactions) technology for revealing thousands of chromatin-associated RNAs (caRNA) and their respective genomic interaction sites (Current Biology, 2017; Nature Protocols, 2019). Leveraging MARGI, we and our collaborators characterized caRNA’s roles in 3D organization of the nucleus (iScience 2018a), modulation of gene expression during progression of diabetes mellitus in blood vessel endothelium (bioRvix, 2019), and the biogenesis of fusion RNAs (PNAS 2019a).
We contributed to discover that the earliest cell fate decision in mouse is made sooner than the commonly thought 8-cell stage (Genome Res, 2014). Our Rainbwo-seq technology combined tracing of cell division history and single-cell RNA sequencing into one experiment (iScience 2018b).
We developed SILVER-seq for extracellular RNA (exRNA) sequencing from ultra-small volumes of liquid biopsy, solidifying a basis for future in vitro diagnostic trials using finger prick blood (PNAS, 2019b; Current Biology, 2020).
We contributed to reveal that transposons are indispensable regulatory sequences in the mammalian genomes. Species-specific transposons are required for preimplantation embryonic development in humans and other mammals (Genome Res, 2010). Nature highlighted this discovery as “Hidden Differences”, reporting that “transposons or 'jumping genes' had hopped in front of the genes, changing their regulation” (Nature, 2010). We contributed to establishing the proof-of-principle that cis-regulatory sequences can be annotated by cross-species epigenomic comparison (Cell, 2012).
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