- The University of Texas MD Anderson Cancer Center
- Location: Smithville, TX
- Job Number: 7065231
- Posting Date: Mar 11, 2020
- Application Deadline: Open Until Filled
Job DescriptionDespite recent advances in immunotherapy, lung adenocarcinoma remains the leading cause of death in smokers. A significant fraction of lung adenocarcinomas display somatic activating mutations in the KRAS oncogene. KRAS-mutant lung adenocarcinoma, compared to other solid tumors, displays very poor clinical outcomes. Despite the overwhelming public health burden of KRAS-mutant lung adenocarcinoma, there are very few, if any, strategies for early treatment of this disease -- largely due to a very poor understanding of molecular changes that drive its initiation and development. One of our laboratory's goals is to delineate early immune events in the transition of smoking-exposed normal airway to KRAS-mutant lung adenocarcinoma. Understanding these changes may pave for the development of new prevention (immune-based) strategies for KRAS-mutant lung cancer. Our laboratory is looking for a postdoctoral fellow to embark on different vignettes in the immune evolution of KRAS-mutant lung cancer including understanding the dynamic interplay between host defense (including immunomodulatory) responses, tumor-initiating inflammation and microbiome dysbiosis (local and systemic) in the development of the malignancy. There will be opportune elements for the candidate postdoctoral fellow at MD Anderson Cancer Center to collaborate with physician and physician-scientists to gain translational insights from laboratory-based findings. We are seeking a postdoctoral fellow whose motivation and ambition matches these exciting and timely projects. The postdoctoral fellow must have abundant experience in immunology, oncoimmunology, cancer biology and molecular biology. Technically, the candidate postdoctoral fellow must have abundant/adequate experience in animal modeling and work, flow cytometry, immunohistochemistry/cytochemistry, cell culture as well as basic molecular and cellular biology techniques. Experience in microbial (in vivo) research and genomics is a plus. The candidate postdoctoral fellow is also required to display good to excellent communication skills in English (written and oral) as well as showcase a spirit for teamwork.
Diversity and inclusion at MD Anderson are not just important; they are essential. We take an expansive view of diversity, considering differences in race, ethnicity, sexual orientation, gender and religious beliefs, as well as communication styles, thought, skill and ambition. We constantly examine our culture to create an inclusive working environment that effectively attracts, retains, develops and utilizes the skills and talents of all employees. Our Diversity Council develops strategies to attract and retain superior talent and enhance workforce diversity and inclusion. We also offer multiple diversity training programs to our employees.
Translational Molecular Pathology
2130 W. Holcombe Boulevard Suite 910