Postdoctoral Researcher- Immunology and Host-Pathogen Interactions
- Albert Einstein College of Medicine
- Location: New York City, NY
- Job Number: 7062623
- Posting Date: Dec 6, 2019
- Application Deadline: Feb 6, 2020
Job DescriptionHelp us weaponize the immune system to treat HIV and other viral diseases! The Goldstein laboratory at the Albert Einstein College of Medicine in New York City is recruiting two highly motivated, enthusiastic and productive Postdoctoral Research Scientists with backgrounds in cellular immunology, molecular biology and/or neuroscience to accomplish this goal.
Research: The Goldstein lab is developing and performing pre-clinical testing of novel immunostimulatory biologics to weaponize the human immune system against viral infections by boosting anti-viral T cell immunity. We are developing and evaluating novel anti-HIV CAR-T cells and other HIV cure strategies (Science Translational Medicine 2019:504:eaav5685, J Virol. 2019;93:pii: e02051-18, J Virol. 2017;91:pii: e02412-16 and J Virol. 2017;91:pii: e00937-17). In addition, we are utilizing sophisticated protein architecture and engineering principles to design a new class of multispecific biologics capable of driving in vivo epitope-specific stimulation of T cell responses with potent anti-viral activity. These biologics are being combined with RNAseq and single-cell RNA-seq analysis to correlate gene expression by different costimulatory pathways with the potency of anti-viral T cell activity. We are also utilizing novel HIV transgenic mouse models we have developed in combination with next-gen sequencing and single-cell RNA-seq analysis to investigate the in vivo mechanisms by which opioids alone and in combination with HIV infection compromise the BBB and induce neuroinflammation and cognitive decline to identify druggable targets.
Environment: The Goldstein lab collaborates with investigators at multiple leading academic research institutions and biotech companies and provides the opportunity for substantial creativity and innovation, collaboration with bioengineers, immunologists, and clinicians, and publication of high impact papers and patents. Lab members participate and benefit from sophisticated core facilities and programs within the Department of Microbiology & Immunology, Einstein-Rockefeller Center for AIDS Research (which Dr. Goldstein directs) and throughout the medical school including weekly invited seminars by leading investigators, journal clubs, work-in-progress seminars, workshops as well as social and professional events organized by the Einstein Postdoc office.
Qualifications: The ideal candidate should have a PhD in immunology or a related field and expertise in at least one of the following areas:
• Immunology: lymphocyte, macrophage and microglial cell culture; T cell killing assays; lentiviral production and transduction; flow cytometry; adoptive T cell transfer; and virus infection assays.
• Molecular Biology: DNA/RNA processing and extraction; quantitative RT-qPCR;
• sequence analysis; protein engineering, expression and induction systems; and bioinformatic analysis of transcriptomes.
• Mouse work: Transgenic breeding; blood and urine collection; survival surgery; necropsy and spleen, lymph node and brain analysis; retoorbital and tail-vein injections; ectopic xenograft mouse models; viral infection models, mouse behavioral testing.
Salary: Salary is commensurate with recommended NIH postdoctoral salary guidelines funded by NIH research grants. https://www.nationalpostdoc.org/page/Stipends
Application Process: Interested individuals should send cover letter, CV, and contact information for three references to Dr. Harris Goldstein, Professor of Microbiology & Immunology and Pediatrics and Charles Michaels Chair of Autoimmune Diseases at the Albert Einstein College of Medicine at firstname.lastname@example.org. Applications will not be considered if they do not directly address the applicant's suitability and interest for this position and provide direct contact information for a current supervisor. Visa sponsorship will be considered for a foreign PhD scientist with excellent training and abilities that include well-developed English verbal and writing skills.
The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Einstein seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence, and the communities we serve.
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