We are an interdisciplinary group of scientists, physicians and engineers. Our laboratory is an NIH funded group that has pioneered surgical, imaging and histological techniques that allow us to understand the mechanisms that underlie the fetus’ ability to regeneratively heal cutaneous wounds and the development of novel therapies to achieve scarless wound healing in postnatal tissues. We aim to discover the underlying principle of some of the most fundamental questions about regenerative tissue repair: what is the role of inflammation in scarring? How mechanical tension modulates the inflammation and scarring outcomes?, What is the role of the ECM in fetal tissue repair?, and finally the crosstalk between ECM, immunoregulation and mechanotransduction in tissue repair outcomes. If the goals of this work are realized, there may be significant implications, not only for treatment of dermal wounds, but also for a broad range of diseases and conditions which are characterized by excessive fibroplasia, such as kidney and lung fibrosis and in impaired states such as diabetes.
The applicant will participate in a variety of ongoing basic science, model development, bioengineering, and translational studies. Must possess advanced molecular biology skills including PCR, Chip, cloning of plasmids, lentiviral vector production and complete characterization of transduction and cloning efficacy. The applicant should also have basic laboratory skills including primary animal and human cell isolation, cell and tissue culture, light and fluorescence microscopy, image processing and analysis, rodent handling and anesthesia as well as functional, histological, molecular biology, and biochemical analyses. The applicant must have excellent organizational skills with great attention to detail and be capable of independent as well as collaborative work, possess outstanding interpersonal skills and the ability to create and maintain excellent working relationships in a team environment. Multitasking abilities, flexibility, and adaptability to changing and challenging environment are essential.