- University of Leeds
- Location: Leeds, United Kingdom
- Job Number: 7121604 (Ref #: MHLCM1319)
- Posting Date: Jan 20, 2023
Overview of the Role
This new and exciting position is funded by the British Heart Foundation and will enable us to extend our studies on the functions and regulations of Piezo1 mechanosensitive channel. Piezo1 channel is a critical mechanical sensor in endothelial cells, red blood cells and other cell types such as cardiac fibroblasts. Mutations on Piezo1 have been shown to result in a number of cardiovascular diseases. Building a detailed molecular and dynamic understanding of Piezo1, which will complement the available functional and regulatory data, will fill an important gap in our understanding of the functions and regulations of this biologically important channel.
You will use modelling and simulation tools to perform molecular dynamics simulations of Piezo1 channel in complex model membranes both at the coarse-grained and atomistic resolution. These simulations will facilitate us to address key questions about the regulatory mechanism of Piezo1 by important endogenous substances. You will work in the group of Dr Jian Shi at the Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), and the work will involve close and interactive collaboration with the groups of Dr Antreas Kalli, Prof David Beech and Prof Lee Roberts within LICAMM.
As Research Fellow your main duties will include:
These duties provide a framework for the role and should not be regarded as a definitive list. Other reasonable duties may be required consistent with the grade of the post.
Jian Shi, Associate Professor
Email: [email protected]
|Location:||Leeds - Main Campus|
|Faculty/Service:||Faculty of Medicine & Health|
|School/Institute:||Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM)|
|Section:||Discovery and Translational Science Department (DTSD)|
|Salary:||£35,333 to £42,155 per annum|
|Post Type:||Full Time|
|Contract Type:||Fixed Term (18 months, 11 July 2023 to 10 January 2025 - due to external funding)|
|Release Date:||Thursday 19 January 2023|
|Closing Date:||Thursday 23 February 2023|
The University community is made up of a wide range of people with diverse backgrounds and circumstances, which we value and regard as a great asset. As part of our continued commitment to equality and inclusion, we strive to create an environment where everyone can reach their full potential and have a real opportunity to participate in and contribute to our activities.