Job Description

An opportunity for a Bioinformatician is available at Lund Stem Cell Center, Lund University, Sweden. The post holder will join a dynamic and multidisciplinary environment and will play a key role in our efforts to decipher the molecular events leading to transformation, therapy resistance, and rational targeting of blood malignancies. The successful candidate will assist with the design, analysis, and interpretation of generated data, and is at the same time expected to develop new research arms within the scope of the lab.

Qualifications and skills:
-Applicants will have a PhD in bioinformatics or a related subject.
-Demonstrated experience in analysis of genome scale biological datasets, such as bulk RNA-seq, ATAC-seq, CUT&Tag, gene expression meta-analysis, and analysis of regulatory elements in the genome
-Proficiency in analysis of single cell datasets: single cell RNA-seq, single cell ATAC-seq, and single cell multi-omics analysis of gene expression and chromatin accessibility
-Expertise in data mining, statistics, gene expression meta-analysis, analysis of regulatory elements in the genome, multi-omics data integration
-Strong publication record in peer-reviewed journals.
-Excellent personal initiative and communication skills; should be able to work and communicate with colleagues in the ‘wet lab’ and train group members as and when required.
-Advanced knowledge of Python, R/Bioconductor, Linux/UNIX environment

The lab:
Lund University is ranked as world’s one of the top universities. Our ‘stem cells and leukemia lab’ headed by Göran Karlsson (PhD) is part the ‘Division of Molecular Hematology’ at Lund University. We aim to investigate molecular events within stem cells during normal and malignant hematopoiesis. With our unique access to patient samples, and using high-throughput screening, we have identified novel molecular features of drug-resistant leukemic stem cells. Paired with analysis of master transcriptional regulators, and biological pathways, we intend to find and target the ‘Achilles heal’ of stem cells for translational impact.
https://portal.research.lu.se/sv/persons/g%C3%B6ran-karlsson/publications/

The location:
Lund is vibrant city in southern Sweden with roots in medieval times while hobnobbing with modernity. Home to millennium old cathedral, the city prides itself for being a seat of advanced learning and technology (http://www.lund.se/en/).

What we offer:
Start date: As soon as possible
Duration: Two years
Environment: High performance computing facilities at Lund University; opportunity to interact with Bioinformatics core group within the division
Funding: Funding is available but the applicant is expected to apply for extra-mural funding