- UT Southwestern Medical Center
- Location: Dallas, TX
- Job Number: 7079718
- Posting Date: Jun 10, 2021
- Application Deadline: Open Until Filled
Job DescriptionLife, as we know it, is a dynamic network of metabolic reactions that take nutrients from the environment and convert them into the building blocks and energy that cells need to grow and function. Each cell has a unique set of biosynthetic and energetic demands that must be met to ensure normal homeostasis. As a result, cells must establish distinct metabolic states to meet those demands. Disruption of these mechanisms can lead to severe developmental disorders and promote the progression of diseases such as cancer, neurodegeneration, and reproductive disorders.
Our primary goal in the lab is to understand the dynamic changes in metabolic programs that support developmental and disease progression. Using a combination of genetics, molecular biology, and system based approaches (metabolomics, proteomics, and transcriptomics) we are investigating metabolic mechanisms that support development and disease progression. Our work focuses on three key areas:
1) Understanding the role of metabolism in cellular quiescence.
2) Examining how mitochondrial metabolism impacts growth and differentiation.
3) Investigating how cellular metabolism regulates developmental signaling pathways.
We are currently recruiting postdoctoral fellows interested in developing projects in the following areas:
A) Examining the links between mitochondrial metabolism and cellular proteostasis
B) Determining how biochemical changes in mitochondria drive metabolic reprogramming during development and cancer recurrence .
C) Assessing how changes in mitochondrial metabolism control cell fate during development and tumor initiation.
A PhD in Biomedical science related field is required.
All post-docs are given independent projects that they are welcome to take with them to start their own Research groups.