POST-DOCTORAL SCHOLAR position to study altered cell signaling & trafficking in Alzheimer’s disease (AD)
- PENN STATE UNIVERSITY College of Medicine
- Location: Hershey, PA
- Job Number: 7063192
- Posting Date: Jan 21, 2020
- Application Deadline: Open Until Filled
Job DescriptionSeeking recent Ph.D. graduate for Post-doc position beginning immediately in the Mulder Lab, Dept. of Biochemistry & Molecular Biology, Penn State College of Medicine, Hershey, PA. Research is focused on neuronal cell signaling and trafficking. Models include induced pluripotent stem cell (iPSC) models and hippocampal neurons from mouse models of sporadic Alzheimer’s disease (sAD). Research also pertains to Ras/Ras-like GTPases, km23-1/dynlrb1, motor proteins, dynein, growth factors, endosomes, Golgi, exosomes, and amyloid protein processing.
Requirements include a Ph.D. in a relevant field, as well as relevant peer-reviewed molecular/cell biology publications. Must have demonstrated hands-on experience with mammalian cell culture and basic molecular/cell biology techniques (ie, WB, IP/blot, PCR, transfection, construct preparation, shRNA/CRISPR, fluorescence staining and microscopy, live imaging). Preference will be given to applicants with relevant expertise related to neuronal cell signaling/trafficking, stem cells, and AD.
Please submit CV and contact information for 3 referees to Dr. Kathleen M. Mulder at firstname.lastname@example.org. In your cover letter, please indicate which of your publications demonstrate your hands-on experience in the relevant molecular/stem cell techniques.
Penn State Hershey College of Medicine is located in a scenic countryside setting, with affordable living minutes from work, and moderate climate conditions. Located near the state capitol, Harrisburg, in south central PA, it is approximately 1.5 hours from Philadelphia, PA, or Baltimore, MD, and about 3 hours or less from New York City or Washington, DC. Modern laboratory space is abundant and research instrumentation, technologies, and core facilities are state-of-the-art.
Mulder Lab Research Interests:
We have identified the TGF-beta receptor-interacting protein km23-1/dynlrb1, which plays an important role in TGF-beta signal transduction, as well as in dynein-mediated intracellular transport of signaling cargoes to specialized locales. km23-1 also functions as a critical platform for the assembly of small GTPases (such as Ras, Rabs) underlying its critical roles in cell signaling, motility, polarity, intracellular transport, cytoskeletal dynamics, and TGF-beta receptor signaling. We are also investigating mechanisms of signaling and trafficking involving migration/invasion, actin cytoskeleton, motor proteins, intracellular trafficking, Ras, MAPKs, Smads, and dynein. Additional studies address how these events are altered in neurodegenerative diseases and in human cancer. The overall focus of the Mulder Lab is the identification of novel signal transduction-based therapeutics for human pathologies such as Alzheimer’s disease and cancer.
BIOCHEMISTRY & MOLECULAR BIOLOGY
500 UNIVERSITY DR, MC H171 DEPT OF BIOCHEMISTRY & MOLECULAR BIOLOGY