Participate in a project to study the function of maternal effect genes that play a role in fertility, reproductive success and trophoblast differentiation. We are specifically interested in genes that encode proteins of the subcortical maternal complex of the oocyte and early embryo. The project primarily uses cell culture, including mouse and human embryonic stem cells, and mouse models. The project will involve investigating how they affect early development and reproductive outcomes via epigenetic mechanisms. The postdoc will work on NIH-funded projects to characterize the consequences of inactivation these proteins in embryonic stem cells and mice. Experiments will involve advanced cell culture methods, high throughput epigenomics and expression profiling and appropriate validation studies. Mouse breeding, including in vitro fertilization and, embryo transfer and cross fostering of offspring, detailed placenta and embryo characterization.
The impact of this research will be to better understand pathways and molecules involved in early embryo and trophoblast development and how maternal mutations contribute to abnormal reproductive outcomes, which may ultimately lead to better diagnosis and treatment of these conditions.
The postdoctoral research position is in Dr. Van den Veyver’s research laboratory in the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital and Baylor College of Medicine
The following skills are highly desired for this position: