Date Posted: Sep 23, 2018
Application Deadline: Open Until Filled
Postdoc - Research Scientist : Chromatin - DNA repair - nuclear dynamics (Chiolo Lab)
At the University of Southern California, Los Angeles, creativity and excellence are fundamental to our success. The University of Southern California is a major force in advancing biomedical research and science education in the U.S. and beyond.
The Chiolo Laboratory is seeking two creative, accomplished, and highly motivated postdoctoral scholars or research scientists for an NSF- and an NIH-funded research position. The timing is perfect to be involved in projects at the forefront of a new field of high relevance for human health. The Chiolo lab combines multi-disciplinary approaches to understanding the molecular mechanisms of heterochromatin repair and genome stability. Heterochromatin is mostly composed of highly repeated sequences prone to aberrant recombination. The unique mechanisms responsible for coordinating DNA repair in heterochromatin are just emerging, and these studies have major implications for our understanding of cancer etiology and aging. We combine sophisticated NGS sequencing and super resolution and live imaging approaches, with traditional cell biology, biochemical and genetic techniques, in mouse and Drosophila cells.
Ideal candidates will have strong interest in the mechanisms of DNA repair and chromatin/chromosome dynamics, excellent publication record, enthusiasm for scientific research, creativity, a collaborative nature, and good communication skills. Individuals with expertise in chromatin immunoprecipitation (ChIP), NGS data analysis, and cell biology are particularly encouraged to apply.
To apply, please send a single PDF file that includes the following to Prof. Irene Chiolo (firstname.lastname@example.org), and include ‘postdoc application’ in the subject of the e-mail:
1. A cover letter that describes your research and career goals, and your expertise or experience related to DNA repair, nuclear structure and dynamics, or chromatin responses.
2. A curriculum vitae, including a publication list with a brief (2-3 sentence) description of your contributions to published work.
3. Names and contact information for 3-5 references.
More information about the lab can be found at: http://www-bcf.usc.edu/~chiolo
1) Caridi PC, D’Agostino C, Ryu T, Zapotoczny G, Delabaere L, Li X, Khodaverdian V, Amaral N, Lin E, Rau A, Chiolo I*. (2018) Nuclear F- actin and myosins drive relocalization of heterochromatic breaks. Nature. 559: 54–60.
2) Ryu T., Spatola B., Delabaere L., Bowlin K., Hopp H., Kunitake R., Karpen GH, Chiolo I* (2015) Heterochromatic breaks move to the nuclear periphery to continue recombinational repair. Nature Cell Biology. 17:1401-11.
3) Chiolo I*, Minoda A, Colmenares SU, Polyzos A, Costes SV, Karpen GH* (2011). Double-strand breaks in heterochromatin move outside a dynamic HP1a domain to complete recombinational repair. Cell 144:732-44.