Date Posted: Apr 16, 2018
Postdoctoral Associate needed to study NAD kinase (NADK) as a redox vulnerability for the treatment of pancreatic ductal adenocarcinoma (PDAC). The goals of the project are focused on elucidating the NADK biology and its relationship to the newly-described Glutamine-Reprogramming Pathway (GRP) by using PDAC cell models. Successful candidate will collaborate with the Center for Drug Discovery at BCM to develop drug screening assays for NADK inhibitors. We will also employ CRISPR to target NADK in genetically-engineered mouse models of PDAC that closely recapitulate the human disease and in the future, will serve as a pre-clinical testing platform for adjuvant therapies.
Data collection, processing and analysis
Presentation of project results to internal and external parties
Engaged writing of publications and reports
May be responsible for training staff, graduate assistants, or student employees
Required: PhD in genetics, molecular biology or biochemistry or equivalent.
Previous experience with cancer metabolism study is preferred
Excellent oral and written communication skills.
Experience with cell culture, gene expression studies/transcriptomics, cloning, general molecular biology techniques, and statistics.
Must be able to work independently and within a team.
Experience with mouse husbandry.
Excellent organizational and project management skills.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.