Date Posted: Feb 24, 2018
- Indiana University
- Location: Bloomington, IN
- Job Number: 7050115
- Posting Date: Feb 24, 2018
The Mitra lab in Medical Sciences Program, Indiana University School of Medicine, Bloomington is seeking a Postdoctoral Fellow who will lead OCRFA-funded project to understand the role of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in mutant p53-mediated signaling in high-grade serous ovarian cancer (HGSOC). About 96% of HGSOC harbor mutation in tumor suppressor gene, TP53. The goal of the project is to define and characterize important molecular signaling events of mutant p53-mediated tumor progression and chemo-resistance. Our research integrates in vitro organotypic 3D culture model of metastasis, mouse models, patient tumors, microarray, sequencing and proteomics based approaches coupled with cell biology and molecular biology techniques. The successful applicant will also use CRISPR and small molecule inhibitors that might represent therapeutic targets.
Candidate must be enthusiastic, passionate and self-motivated with a commitment to career development. The candidate must be able to work independently and efficiently manage concurrent projects and while possessing a strong commitment to contributing intellectually and interpersonally toward a positive and stimulating lab environment.
Candidates with Ph.D. in cell/molecular biology, biochemistry or other closely related field can apply. Extensive experience in molecular biology, mammalian cell culture, proteomics, cell signaling and metabolomics will be preferred.
To apply: Interested applicants should send a single PDF file including cover letter, CV, one-page statement of research interests and contact information for three references to email@example.com
Indiana University is an Equal Opportunity/Affirmative Action Employer, Educator and Contractor, M/F/D and strongly committed to achieving excellence through cultural diversity. The university actively encourages applications and nominations of women, persons of color, applicants with disabilities, and members of other underrepresented groups.
Bloomington is known as the "Gateway to Scenic Southern Indiana" and is the home to the original and the largest campus of Indiana University. Check this link for an overview of life in Bloomington: http://bloomington.medicine.iu.edu/about-us/life-in-bloomington/
Employer’s website: https://www.smitralab.com