Date Posted: Feb 1, 2018
We are seeking applications from qualified candidates with expertise in the biology of human embryonic and induced pluripotent stem cells (iPSCs) with CRISPR editing of the neurodegenerative disorder-associated SNPs. Candidates with a strong background in neuronal differentiation of iPSCs, organoid models, CRISPR editing, and molecular biology are encouraged to apply. They will work in a highly collaborative environment, focusing on investigating the functional consequences of disease-associated SNPs on neuronal development, gene expression and excitability, and post-translational modifications of disease-associated molecules in 2D or 3D conditions.
The research will be based at the Laboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, but will involve interactions with collaborators in other institutes in Boston area. The main focus of the lab is the identification and therapeutic intervention of target genes and cell types for the treatment or prevention of neurodegenerative disorders, such as Alzheimer’s disease and other tauopathies.
The ideal candidates will be expected to work independently in stem cell tissue culture engineering and molecular editing. They will keep records and data of all scientific experiments according to established procedures. They also will draft technical reports, manuscripts for scientific journals, and present work internally and externally as needed. They are also expected to occasionally supervise students, act as a source of information and advice to other members of the group on scientific protocols and experimental techniques.
Each applicant must possess an advanced degree (M.D. and/or Ph.D.) in a relevant field. Candidates with experience in iPSC culture system, genetic engineering and neurobiology are encouraged to apply. The ideal candidates should be team players with high scientific standards and communication skills, and have the ability to work in an interactive, fast-paced environment.
The following links provide more information about the laboratory and institution:
Laboratory of Molecular NeuroTherapeutics: http://www.bumc.bu.edu/busm-pm/faculty/faculty-profiles/ikezu/
Department of Pharmacology and Experimental Therapeutics: http://www.bumc.bu.edu/busm-pm/
Boston University School of Medicine: http://www.bumc.bu.edu/busm/profile/tsuneya-ikezu/
To inquire, please send the following files to email@example.com: Curriculum vitae (including publication list), a statement of research interest including brief description of past work, and contact information of three references.