Date Posted: Dec 19, 2017
Application Deadline: Mar 15, 2018
- Boston University
- Location: Boston, MA
- Job Number: 7049308
- Posting Date: Dec 19, 2017
- Application Deadline:
Mar 15, 2018
The Fuxman Bass lab (www.fuxmanlab.com) in the Biology Department at Boston University is seeking a highly motivated post-doctoral researcher with a background in molecular biology, genomics or a related field to join our team. We are seeking a dynamic and collaborative individual who will be responsible, as a member of a team, for designing and executing studies focused on defining the molecular mechanisms by which disease-associated mutations rewire transcriptional programs.
Genome-wide association studies have identified thousands of variants associated with disease, most residing in noncoding regions of the genome and potentially affecting gene expression. However, except for few examples, the casual variants and target genes are unknown due to the presence of multiple non-functional variants in linkage disequilibrium. Further, in most cases, the mechanisms by which noncoding disease variants affect gene regulation have not been determined. The goal of this project is to tackle these gaps in Biomedical Research by generating an end-to-end pipeline to identify and functionally characterize thousands of disease-associated noncoding variants. This will be performed by integrating massively parallel reporter assays to identify functional variants, with enhanced yeast one-hybrid assays to identify changes in transcription factor binding, and cell based assays for functional validation and follow-up. Collectively, we aim to generate an unprecedented resource for thousands of noncoding variants that will provide insights into disease mechanisms, and will lay a foundation for the design of novel therapeutics.
Experience in molecular biology, cell culture, bioinformatics, and/or genomics are recommended. If you are interested, please send an email to firstname.lastname@example.org with your CV and a cover letter.
Boston University is an Equal Opportunity/Affirmative Action/Equal Access Employer.