Postdoctoral opportunities in Stem Cell Biology and Gene Therapy

Lund Stem Cell Center, Lund University

Job Title:	Postdoctoral opportunities in Stem Cell Biology and Gene Therapy
Job Number:	4007762
Date Posted:	07/27/2010
Application Deadline:	Open Until Filled

Job Description

Postdoctoral fellowship positions are available within Professor Stefan Karlsson’s group to work on the regulation of hematopoietic stem cells and development of cell and gene therapies. We are investigating the regulation of stem cells by the Smad signaling pathway and are working on the discovery of novel stem cell regulators to increase self-renewal and expand human and murine hematopoietic stem cells. The laboratory also investigates two human hematological disorders, Diamond Blackfan anemia and Gaucher disease to clarify disease mechanisms and develop cell and gene therapies. The successful postdoctoral candidate can select between different projects, depending on interests and expertise.

The scientific environment is excellent and is a part of The Hemato-Linne Program at Lund Stem Cell Center. The Laboratory has an extensive network of local and international collaborators.

Selected Publications from The Karlsson Laboratory

Larsson, J, Goumans M-J, Jansson-Sjöstrand L, van Rooijen M, Ward, D, Levéen, P, Xu, X, ten Dijke, P, Mummery, C L, Karlsson, S (2001). Abnormal vascular development, but intact hematopoietic potential in transforming growth factor-ß receptor I deficient mice. EMBO J 20: 1663-1673.

Woods, N-B, Muessig, A, Schmidt M, Flygare, J, , Olsson, K, Salmon, P, Trono, D, von Kalle, C, Karlsson, S (2003). Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis. Blood 101:1284-9.

Larsson J, Blank, U, Helgadottir, H, Levéen P, Björnsson JM, Ehinger, M, Goumans, M-J, Fan X, Karlsson, S (2003). TGF-β signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro. Blood 102: 3129-3135.

Flygare J, Kiefer T, Miyake K, Utsugisawa T, Hamaguchi I, Da Costa L, Richter J, Davey E, Mattsson H, Dahl N, Wizerowich M, Trono D, Karlsson, S (2005) Deficiency of Ribosomal Protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond Blackfan anemia. Blood 105: 4627-4634.

Blank U, Karlsson G, Moody J, Utsugisawa T, Magnusson M, Singbrant S, Larsson J, Karlsson, S (2006). Smad7 promotes self-renewal of hematopoietic stem cells in vivo. Blood 108: 4246-4254.

Berglin-Enquist I, Nilsson E, Ooka A, Månsson J-E, Olsson K, Ehinger M, Brady RO, Richter J, Karlsson, S (2006). Effective cell and gene therapy in a murine model of Gaucher disease. Proc. Natl. Acad. Sci. USA 103:13819-13824.

Karlsson G, Blank U, Moody JL, Ehinger M, Singbrant S, Deng C-X, Karlsson, S (2007). Smad4 is critical for self-renewal of hematopoietic stem cells. Journal of Experimental Medicine 204:467-474.

Magnusson M, Brun ACM, Miyake N, Larsson J, Ehinger M, Björnsson JM, Wutz A, Sigvardsson M, Karlsson, S (2007). Distinct hematopoietic cell fates are regulated by graded expression of HoxA10. Blood 109: 3687-3696.

Flygare J, Karlsson, S (2007). Diamond Blackfan anemia: Erythropoiesis lost in translation. Blood 109: 3152-3160.

Berglin-Enquist I, Lo Bianco C, Ooka A, Nilsson E, Månsson J-E, Ehinger M, Richter J, Kirik D, Karlsson, S (2007). Murine models of acute neuronopathic Gaucher disease. Proc. Natl. Acad. Sci. USA 104:17483-17488.

Blank U, Karlsson G, Karlsson, S (2008). Signaling pathways governing stem cell fate. Blood 111: 492-503.

Karlsson G and Karlsson, S (2008). Stem cell regulation and host defence: The logic and the paradox. Cell Stem Cell 2: 1-2.

Berglin-Enquist I, Nilsson E, Månsson J-E, Ehinger M, Richter J, Karlsson, S (2009). Successful low-risk hematopoietic cell therapy in a mouse model of type 1 Gaucher disease. Stem Cells 27:744-752.

Singbrant Söderberg S, Karlsson G, Ehinger M, Jaako P, Stadtfeld M, Graf T, Karlsson, S (2010). Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture. Blood 115: 4689-4698.

- Candidates with a strong publication record will be considered.

- Please include a list of three professional references (E-mail address and phone number).

- Applications sent by e-mail will not be considered.

Contact:	Stefan Karlsson Lund Stem Cell Center, Lund University BMC A12 Lund, Sweden Email: stefan.karlssonmed.lu.se
Online Application:	Apply for this job from Employer's website

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